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Glycine for Sleep – Unmasking its Efficacy and How to Harness it for Quality Sleep

Posted on April 04 2023

A symphony of stars twinkles overhead as the moon makes its nightly ascent. It's a serene scene, but for many, the tranquility of night brings frustration rather than relaxation. For those who yearn for a good night’s sleep but find it elusive, an unexpected hero might come in the form of a humble amino acid – glycine. This seemingly modest compound has been making waves in the realm of sleep science, offering hope to those seeking the nirvana of a restful night. In this article, we delve deep into the world of glycine, exploring its characteristics, its role in promoting sleep, and how to incorporate it into your sleep routine.

What Is Glycine?

At its core, glycine is one of the twenty amino acids that serve as the building blocks of proteins in the human body. It's classified as a non-essential amino acid, meaning our bodies can produce it independently, although it can also be obtained from various food sources, such as meat, fish, dairy, and certain types of beans and vegetables.

Glycine's structure is the simplest among all amino acids, yet its roles within the body are manifold and complex. It's a vital participant in numerous biochemical processes, contributing to everything from the production of DNA and collagen to the regulation of digestion and blood sugar levels.

However, glycine's impact stretches further, extending into the realm of the central nervous system. Here, it takes on the role of a neurotransmitter – a chemical messenger that transmits signals across nerve cells, influencing everything from mood to muscle movement. Glycine's influence as a neurotransmitter is particularly intriguing when it comes to one of our most fundamental daily processes – sleep.

In the brain, glycine functions as an inhibitory neurotransmitter, meaning it helps to slow down the activity of nerve cells, fostering a state of calm and relaxation. This property of glycine has led researchers to delve into its potential role as a sleep aid, a topic we'll delve into in the following sections.

Benefits: How Does Glycine Help You Sleep?

Glycine's impact on sleep may seem surprising at first glance, given its status as a seemingly simple amino acid. However, when we delve into the science behind its effects, it becomes clear that its influence on our nighttime rest is rooted in a combination of physiological mechanisms and biochemical interactions within our bodies.

Temperature Regulation

One of the key factors in initiating sleep is the natural drop in body temperature. This decrease signals to our bodies that it's time to transition from the activities of the day to the restfulness of night. Glycine aids in this process by acting on the suprachiasmatic nucleus (SCN), the body's 'internal clock' that regulates sleep and wake cycles. The SCN controls the release of melatonin, the sleep hormone, in response to changes in light and temperature. By promoting vasodilation, or the widening of blood vessels, glycine facilitates heat loss and helps to lower body temperature, thus encouraging the onset of sleep.

Neurotransmitter Activity

In the central nervous system, glycine functions as an inhibitory neurotransmitter. It works by reducing the excitability of neurons, promoting a state of calm and quiet within the brain. This slowing down of neuronal activity contributes to the reduction of anxiety and agitation, conditions often associated with sleep difficulties. By fostering a state of relaxation, glycine can help individuals to fall asleep faster and experience a more restful sleep.

Sleep Architecture

Sleep is not a homogenous state but rather is composed of different stages, each with its unique characteristics and benefits. Rapid eye movement (REM) sleep and non-REM sleep stages, including deep sleep, are critical for various functions such as memory consolidation and physical restoration. Glycine has been shown to enhance sleep efficiency by extending the duration of REM sleep and reducing instances of wakefulness during the night. As a result, individuals who supplement with glycine often report feeling more refreshed and alert upon waking, indicative of a more restorative sleep experience.

Anti-Oxidative Effects

Glycine also exhibits anti-oxidative properties, which means it helps combat oxidative stress in the body. Oxidative stress, an imbalance between free radicals and antioxidants, has been linked to sleep disorders. By scavenging free radicals, glycine may contribute to improved sleep by mitigating oxidative stress.

Thus, while it may appear simple, glycine's influence on sleep is multifaceted and profound. Its potential benefits extend from the initiation of sleep to its quality and architecture, making it a promising agent in the quest for better sleep.

How To Take Glycine For Sleep

To optimize glycine's sleep-enhancing benefits, a strategic approach is key. Begin by enriching your diet with glycine-rich foods such as lean meats, dairy, and certain legumes and vegetables. This not only boosts your glycine intake but also enriches your diet with other vital nutrients.

For additional supplementation, glycine is available in various forms-capsules, tablets, or powder. The powdered form offers flexibility with dosage and can be mixed with a beverage of your choice, providing an easy intake method.

The timing of your glycine intake can significantly influence its effectiveness. Aim to take your glycine supplement approximately one hour before bed. This allows your body sufficient time to absorb the amino acid, aligning its calming effects with your bedtime routine.

The commonly recommended dosage for sleep improvement is around 3 grams per day. However, individual requirements may vary, so it's advisable to start with a lower dose, increasing it gradually under the guidance of a healthcare professional.

Remember, safety is paramount. Prior to starting a glycine supplement regimen, consultation with a healthcare provider is recommended, especially for individuals with pre-existing health conditions or those on medication. It's also important to closely monitor your body's response to the supplement and report any unusual symptoms to your healthcare provider.

In essence, the thoughtful use of glycine, considering dietary sources, form of supplementation, timing, dosage, and precautions, can pave the way for better sleep and improved overall wellness.

Other Techniques to Help You Sleep

As we deepen our understanding of sleep, it becomes evident that a holistic approach often yields the best results. While glycine presents a promising avenue, coupling it with other sleep-promoting techniques can create a comprehensive sleep strategy. Here are a few other methods to consider:


Meditation is more than just a practice; it's a journey into the mind that promotes relaxation and fosters a sense of peace. Apps like Mesmerize can help guide you towards a state of relaxation conducive to sleep. Mesmerize combines captivating colors and stunning animations with soothing audio to create immersive experiences that allow your mind to unwind. These carefully crafted visual journeys are designed to help you de-stress, refocus, and bring balance to your busy life. 

With a wide range of customizable visual patterns and calming soundscapes, Mesmerize is tailored to your unique preferences, making meditation more enjoyable and accessible than ever before.

Achieve mindfulness, boost your creativity, get better sleep, improve your mental well-being, and more with this easy-to-use app. Whether you're a meditation newbie or a seasoned zen master, Mesmerize offers an engaging, personalized experience for everyone.

Join the growing community of happy users who have found their zen with Mesmerize. Head tothe App Store or Google Play to download and unlock a world of tranquility today.

Physical Activity

Engaging in regular physical activity is a cornerstone of healthy sleep. Exercise helps regulate the body's internal clock, promotes mood stabilization, and reduces anxiety, all of which contribute to better sleep. It's not just about rigorous workouts-even light activities like walking or stretching can make a significant difference. The key is consistency and finding a routine that you enjoy and can stick to.

Sleep-friendly Environment

Creating an environment conducive to sleep can dramatically improve sleep quality. This involves optimizing factors such as light, noise, and temperature. Consider investing in blackout curtains or an eye mask to block out light, a common sleep disruptor. White noise machines or earplugs can mitigate disruptive noises. Keeping the room at a cool temperature, typically around 60-67 degrees Fahrenheit, can also facilitate sleep.

Limiting Screen Time Before Bed

In our modern, tech-driven world, screen time can significantly impact our sleep. The blue light emitted by devices like smartphones and laptops can interfere with the production of melatonin, the hormone that regulates sleep. Limiting screen time an hour or two before bed can help preserve your body's natural sleep-wake cycle.

Maintaining a Consistent Sleep Schedule

Our bodies thrive on routine, including when it comes to sleep. By waking up and going to bed at the same time each day, you reinforce your body's natural circadian rhythm, promoting better sleep over time. This consistency applies to weekends, too, avoiding the 'social jetlag' that comes from dramatically changing sleep times.

Mindful Eating and Drinking

What we consume can significantly impact our sleep. Try to avoid large meals, caffeine, and alcohol close to bedtime. These can disrupt your sleep cycle and decrease the quality of your sleep.

By integrating these techniques into your sleep routine, alongside glycine supplementation, you are likely to experience a significant improvement in your sleep quality and, by extension, your overall well-being. Remember, it's about finding the right combination that works for your unique needs and lifestyle.


While the quest for a good night's sleep can feel like an uphill battle, there are solutions at hand. Glycine, a simple amino acid, has shown promising results in enhancing sleep quality. Alongside other sleep-improvement techniques such as meditation, regular exercise, and creating a sleep-friendly environment, you might find your path to restful slumber. Remember, every person is unique, and what works for one may not work for all. It's important to experiment and find what works best for you. Sweet dreams are ahead!